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Home > Skin & Beauty > ​Does Azelaic Acid Exfoliate Your Skin?

​Does Azelaic Acid Exfoliate Your Skin?

5 min read
By Sarita Sanke, MD | Dermatology

In this article:

  • How Does Azelaic Acid Work as an Exfoliator?
  • What Are the Benefits of Using Azelaic Acid in Skin Care?
  • Are There Adverse Effects of Azelaic Acid Use?
  • Most-Asked Questions
  • Final Word

Azelaic acid is an amazing ingredient for your skin. It’s a mild exfoliator, meaning it gently removes the dull, dead skin on the surface.

does azelaic acid exfoliate your skin

Think of it as something that breaks down the old layers, revealing smoother and brighter skin underneath. This helps with the skin’s texture, making your skin look and feel better.

Plus, azelaic acid is kind to different skin types, even sensitive ones.

However, you should note that azelaic acid not only smoothes skin by clearing away dead cells but also fights inflammation, making redness and irritation take a backseat.

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Moreover, it works as an antioxidant, shielding your skin from harmful free radicals. (1)(2)

If you’re new to the world of skincare, it is time for you to learn a little more about these famous ingredients. Read on to get all the information on azelaic acid and its exfoliating action.

How Does Azelaic Acid Work as an Exfoliator?

As a dicarboxylic acid, azelaic acid also has mild exfoliating properties. It plays the role of an effective exfoliator through different mechanisms of action that involve intricate processes.

First, it acts as a keratolytic agent, which means it has the power to control the shedding of dead skin cells. This is helpful in preventing the buildup of dead cells on the skin’s surface, contributing to a much smoother and more even complexion. (1)(2)

Second, azelaic acid has the ability to inhibit tyrosinase, the enzyme crucial for melanin production. This helps fade hyperpigmentation, giving you a brighter and more uniform skin tone.

Third, azelaic acid showcases anti-inflammatory effects and alleviates redness. This makes azelaic acid beneficial for those with acne and rosacea.(3)(4)

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Furthermore, azelaic acid aids in preventing the formation of comedones, or clogged pores. By keeping pores clear, azelaic acid reduces the chances of acne development.

Finally, the compound has antibacterial properties, specifically against Propionibacterium acnes, a bacterium associated with acne. (2)(3)(5)

What Are the Benefits of Using Azelaic Acid in Skin Care?

Here are the many positives of incorporating azelaic acid into your daily routine.

Controls and manages acne

Azelaic acid is a potent acne treatment with diverse benefits. Research indicates it promotes skin cell turnover, preventing clogged pores, and effectively eliminates the acne-causing C. acnes bacteria.

Its anti-inflammatory properties also reduce the redness and swelling associated with acne.

Azelaic acid in FDA-approved 20% cream form showed visible results against acne within four weeks, according to a study.

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Additionally, combining azelaic acid with common acne treatments such as glycolic acid, clindamycin, and erythromycin enhances overall treatment efficacy, making it a versatile solution for various acne problems. (5)

Lightens dark spots

Azelaic acid is a significant breakthrough in the treatment of facial hyperpigmentation, particularly in individuals with darker skin tones.

The findings of a study revealed that azelaic acid 20% cream surpassed the control treatment in its ability to lighten dark spots. This was proven to be true by a chromameter analysis, which is a scientific tool used to measure skin color.

Despite reports of slight burning and stinging sensations among participants using azelaic acid, the overall feedback was very positive. Participants had a preference for azelaic acid, reporting smoother skin and heightened satisfaction after its use. (6)

Treats and controls rosacea

Rosacea is a chronic skin disorder characterized by facial redness and involves inflammatory processes. Azelaic acid has demonstrated amazing efficacy in fighting inflammation, offering relief to individuals suffering from rosacea.

A study that investigated the use of a gel formulation containing 15% azelaic acid revealed promising outcomes. This formulation was found to significantly alleviate rosacea symptoms, establishing azelaic acid as a good choice for managing mild-to-moderate cases of this skin condition. (7)(8)

Are There Adverse Effects of Azelaic Acid Use?

Azelaic acid is generally considered safe for topical use, and most individuals experience only mild and temporary side effects.

These effects are usually limited to a mild burning or stinging sensation, accompanied by mild skin tightness and redness in the treated area.

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These reactions are not uncommon, with an estimated 5%–10% of users reporting such experiences.

The occurrence of these side effects is often highest during the initial weeks of azelaic acid application as the skin adapts to the treatment. (5)

Most-Asked Questions

Can I use azelaic acid every day?

According to experts, it is okay to use azelaic acid daily if it suits you.

Which is better for acne – azelaic acid or salicylic acid?

Azelaic acid is a better choice for pregnant women according to research, but for others, salicylic acid remains the first choice. (9)

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Final Word

Azelaic acid exfoliates the skin by acting as a keratolytic, breaking down dead skin cells and promoting a smoother complexion. It also inhibits melanin production, lightening dark spots, and exhibits anti-inflammatory effects, making it effective for acne and rosacea.

Azelaic acid is generally safe, with mild, temporary side effects such as burning or stinging in 5%-10% of users.

References
  1. KL; FA. Azelaic acid.A review of its pharmacological properties and therapeutic efficacy in acne and Hyperpigmentary Skin Disorders.Drugs. https://pubmed.ncbi.nlm.nih.gov/1712709/.
  2. 2.Salimi A, Sharif MakhmalZadeh B, Godazgari S, Rahdar A. Development and evaluation of azelaic acid-loaded microemulsion for transfollicular drug delivery through Guinea pig skin: A mechanistic study. Advanced pharmaceutical bulletin. June 2020. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191225/.
  3. JK; SM. Azelaic acid: Properties and mode of action. Skin pharmacology and physiology. https://pubmed.ncbi.nlm.nih.gov/24280644/.
  4. Azelaic acid topical : Medlineplus Drug Information. MedlinePlus. https://medlineplus.gov/druginfo/meds/a603020.html.
  5. Liu H, Yu H, Xia J, et al. Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne. The Cochrane database of systematic reviews. May 1, 2020. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193765/.
  6. Lowe NJ;RizkD;GrimesP;BillipsM;Pincus S; Azelaic acid 20% cream in the treatment of facial hyperpigmentation in darker-skinned patients. Clinical therapeutics. https://pubmed.ncbi.nlm.nih.gov/9829446/.
  7. The versatility of azelaic acid in dermatology: Journal of …
  8. https://www.tandfonline.com/doi/full/10.1080/09546634.2020.1800579.
  9. A; GH. Azelaic acid 15% gel in the treatment of rosacea. Expert opinion on pharmacotherapy. https://pubmed.ncbi.nlm.nih.gov/18803456/.
  10. Ly S, Kamal K, Manjaly P, BarbieriJS, Mostaghimi A. Treatment of acne vulgaris during pregnancy and lactation: A narrative review. Dermatology and therapy. January 2023. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823189/.
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