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Home > Skin & Beauty > Azelaic Acid for the Skin: Benefits, Uses, and More

Azelaic Acid for the Skin: Benefits, Uses, and More

6 min read
By Sarita Sanke, MD | Dermatology

In this article:

  • What Is Azelaic Acid and Why Should You Use It?
  • How Does Azelaic Acid Work?
  • How Should You Use Azelaic Acid in Your Skin Care Routine?
  • Are There Side Effects Associated with Azelaic Acid?
  • Most-Asked Questions
  • Final Word

If you go out to get new skin care products, you will come across a lot of skin acids such as salicylic acid and glycolic acid, but one gem that remains hidden in the world of skin care is azelaic acid.

azelaic acid for the skin

If it is your first time hearing about this ingredient, do not fret, because although it is gaining a lot of traction, it still is not as well-known as the others.

Azelaic acid is a naturally occurring dicarboxylic acid that is used commonly in topical skin care formulations in a concentration of 20%.

This component has excellent anti-inflammatory actions, because of which it comes in very handy to soothe skin and fight acne issues. (1) It also is famous for managing hyperpigmentation as it has skin-lightening properties.

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Products containing azelaic acid can be used as stand-alone products or combined with other skin care developments for added benefits. (1)

Take a look into the many positives of using azelaic acid for the skin and learn all about this amazing ingredient!

What Is Azelaic Acid and Why Should You Use It?

Azelaic acid is a naturally found compound derived from grains and certain fungi, and it has taken center stage for its ability to make the skin clear and radiant.

This versatile compound comes in various forms, including gel, foam, and cream, and it is appreciated for its effectiveness in addressing common skin concerns such as rosacea and acne. (2)

Here are the benefits of this compound and why you should use it in your skin care regimen.

It is effective against acne

Research suggests that azelaic acid aids in skin cell turnover, preventing clogged pores, while also demonstrating amazing activity in eliminating C. acnes, the bacteria responsible for your annoying pimples. (3)

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Additionally, azelaic acid boasts anti-inflammatory properties, which help address the redness and swelling associated with acne. In fact, 20% azelaic cream is FDA approved for acne treatment and shows results in around 4 weeks.

Research has also shown that this ingredient can enhance the effects of other compounds. Pairing azelaic acid with glycolic acid, clindamycin, or erythromycin improves the overall efficacy of the treatments in reducing all types of acne lesions. (3)

It helps manage rosacea

Azelaic acid has anti-inflammatory and antioxidant powers that shine in treating conditions such as rosacea and acne. Researchers have uncovered strong evidence supporting the role of azelaic acid in rosacea.

Even experts and dermatologists have deemed azelaic acid as a safe and well-tolerated option for various dermatological challenges such as rosacea. (4)

According to a study, azelaic acid can be considered the newest addition to treatments for rosacea as a gel with 15% azelaic acid was found to ease inflammation, making it a great choice for mild-to-moderate rosacea cases. (5)

It improves uneven skin pigmentation

In a study focusing on individuals with darker skin tones, azelaic acid 20% cream emerged as a game changer for treating facial hyperpigmentation.

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It outperformed the control treatment in reducing pigmentation in 24 weeks, as confirmed by the researchers and the chromometer analysis.

Despite causing a slight increase in burning and stinging sensations, azelaic acid was still favored by the study participants, who reported smoother skin and heightened satisfaction.

The results, therefore, established azelaic acid as a highly effective and well-tolerated remedy for hyperpigmentation in individuals. (6)

It is a potential treatment for pregnant women with skin issues

Azelaic acid, a trusted compound in skin care, emerges as a gentle yet potent topical treatment for acne during pregnancy.

With its origins in milk, wheat, rye, and barley, this antioxidant-rich compound is minimally absorbed (4–8%) yet offers a safe haven for expecting mothers. (7)

Azelaic acid also boasts anti-inflammatory and comedolytic properties, which make it effective for managing mild non-inflammatory and inflammatory acne, as well as post-inflammatory hyperpigmentation.

Scientifically supported and considered safe in all trimesters, azelaic acid, at a recommended 20% strength, is a good potential choice for maintaining healthy skin during pregnancy. (7)

How Does Azelaic Acid Work?

Azelaic acid’s potency lies in its anti-inflammatory and antioxidative effects, offering a dual-action shield against the redness and inflammation associated with acne.

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In fact, it goes beyond managing surface-level issues because it also showcases bactericidal properties that combat both Gram-negative and Gram-positive microorganisms. (8)

Remarkably, it even stands up against antibiotic-resistant bacterial strains, making it an excellent force in the fight against acne.

Moreover, this compound can hinder “follicular hyperkeratosis,” which is a process where skin cells build up and clog pores. Azelaic acid steps in to prevent this, keeping your pores clear.(8)

How Should You Use Azelaic Acid in Your Skin Care Routine?

Available in gel, foam, and cream forms, azelaic acid is typically applied twice daily – morning and night.

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To maximize the benefits, cleanse the affected area with a mild soap, avoiding harsh cleansers if you have rosacea. Shake the product container well before use, and gently massage the gel, foam, or cream into the skin.

Resist the temptation to cover the treated area with bandages, allowing the medication to work its magic. Once the skin is dry, feel free to apply makeup or your usual beauty routine.

Remember, prevention is better than cure, so be cautious around the eyes and mouth, washing these areas with water if accidental contact occurs.

Are There Side Effects Associated with Azelaic Acid?

The use of azelaic acid may lead to mild and short-lived side effects. Approximately 5%–10% of users may encounter a temporary burning or stinging sensation, along with skin tightness and redness in the treated area, but these effects generally subside within a few weeks. (3)

Most-Asked Questions

Is azelaic acid suitable for all skin types?

Yes, it’s generally well tolerated by various skin types.

How soon can I see results from using azelaic acid?

Changes may take around 4 weeks to months.

Final Word

Discover the magic of azelaic acid, a skin care gem for acne, pigmentation, and rosacea. Safe for all skin types, it’s available as gel, foam, or cream. Just apply it twice daily for 4 weeks to see results.

References
  1. KL; FA. Azelaic acid. A review of its pharmacological properties and therapeutic efficacy in acne and Hyperpigmentary Skin Disorders. Drugs. https://pubmed.ncbi.nlm.nih.gov/1712709/.
  2. Azelaic acid topical : Medlineplus Drug Information. MedlinePlus. https://medlineplus.gov/druginfo/meds/a603020.html.
  3. Liu H, Yu H, Xia J, et al. Topical azelaic acid, salicylic acid, nicotinamide, sulphur, zinc and fruit acid (alpha-hydroxy acid) for acne. The Cochrane database of systematic reviews. May 1, 2020. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7193765/.
  4. The versatility of azelaic acid in dermatology: Journal of … https://www.tandfonline.com/doi/full/10.1080/09546634.2020.1800579.
  5. A; GH. Azelaic acid 15% gel in the treatment of rosacea. Expert opinion on pharmacotherapy. https://pubmed.ncbi.nlm.nih.gov/18803456/.
  6. Lowe NJ;Rizk D;Grimes P;Billips M;Pincus S; Azelaic acid 20% cream in the treatment of facial hyperpigmentation in darker-skinned patients. Clinical therapeutics. https://pubmed.ncbi.nlm.nih.gov/9829446/.
  7. Ly S, Kamal K, Manjaly P, Barbieri JS, Mostaghimi A. Treatment of acne vulgaris during pregnancy and lactation: A narrative review. Dermatology and therapy. January 2023. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9823189/
  8. JK; SM. Azelaic acid: Properties and mode of action. Skin pharmacology and physiology.. https://pubmed.ncbi.nlm.nih.gov/24280644/.
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